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Pharmacokinetics

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  • Pharmacokinetics
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  • Bioavailability
  • Tissue distribution
  • PK/PD research
  • Dose escalation studies
  • Dose accumulation studies
  • Dose optimisation studies
  • PK on surgically cannulated rodents ( Jugular, femoral and bile duct cannulation )

  • Per oral
  • Intravenous
  • Intramuscular
  • Subcutaneous
  • Subcutaneous
  • Subretinal, intra cranial
  • Intranasal
  • Intratracheal (Repeated 7d/14d/28days dosing of micronized dry powder formulations)
  • Intraperitoneal
  • Opthalmic
  • Topical
  • Surgically incorporated osmotic pumps

Whole blood/Serum/Plasma, Bone marrow, Cerebrospinal fluid (limeted sample volumes) Aqueous humor (limited sample volumes), Saliva sampling, Portal blood Collection Blood sampling by cardiac puncture